Severe cases of pandemic (H1N1) 2009 in children, Germany.
Identifieur interne : 001515 ( Main/Exploration ); précédent : 001514; suivant : 001516Severe cases of pandemic (H1N1) 2009 in children, Germany.
Auteurs : Mathias Altmann [Allemagne] ; Lena Fiebig ; Jana Soyka ; Rüdiger Von Kries ; Manuel Dehnert ; Walter HaasSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Allemagne (épidémiologie), Enfant, Enfant d'âge préscolaire, Facteurs de risque, Grippe humaine (mortalité), Grippe humaine (physiopathologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Indice de gravité médicale, Nourrisson, Pandémies, Prévalence, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H1N1 du virus de la grippe A (pathogénicité), Unités de soins intensifs pédiatriques ().
- MESH :
- génétique : Sous-type H1N1 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- mortalité : Grippe humaine.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- physiopathologie : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : Allemagne, Grippe humaine.
- Adolescent, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Humains, Indice de gravité médicale, Nourrisson, Pandémies, Prévalence, Unités de soins intensifs pédiatriques.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Germany (epidemiology), Humans, Infant, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (epidemiology), Influenza, Human (mortality), Influenza, Human (physiopathology), Influenza, Human (virology), Intensive Care Units, Pediatric (statistics & numerical data), Pandemics, Prevalence, Risk Factors, Severity of Illness Index.
- MESH :
- geographic , epidemiology : Germany.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- mortality : Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiopathology : Influenza, Human.
- statistics & numerical data : Intensive Care Units, Pediatric.
- virology : Influenza, Human.
- Adolescent, Child, Child, Preschool, Humans, Infant, Pandemics, Prevalence, Risk Factors, Severity of Illness Index.
Abstract
In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having ≥1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%-21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.
DOI: 10.3201/eid1702.101090
PubMed: 21291587
Affiliations:
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Le document en format XML
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d'âge préscolaire</term><term>Facteurs de risque</term><term>Humains</term><term>Indice de gravité médicale</term><term>Nourrisson</term><term>Pandémies</term><term>Prévalence</term><term>Unités de soins intensifs pédiatriques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In a hospital-based observational study in Germany, we investigated children admitted to pediatric intensive care units and deaths caused by confirmed pandemic (H1N1) 2009 to identify risk factors and outcomes in critically ill children. Ninety-three children were eligible for our study, including 9 with hospital-acquired infections. Seventy-five percent had underlying chronic medical conditions; neurodevelopmental disorders were most prevalent (57%). The proportion of patients having ≥1 risk factor increased with age in years (odds ratio 1.21, p = 0.007). Of 15 deaths, 11 occurred in a pediatric intensive care unit (case-fatality rate 12%, 95% confidence interval 6%-21%). Only 9% of the children had been vaccinated against pandemic (H1N1) 2009; all survived. Our results stress the role of underlying risk factors, especially neurodevelopmental disorders, and the need for improving preventive measures to reduce severe disease and adverse outcomes of pandemic (H1N1) 2009 in children.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><noCountry><name sortKey="Dehnert, Manuel" sort="Dehnert, Manuel" uniqKey="Dehnert M" first="Manuel" last="Dehnert">Manuel Dehnert</name><name sortKey="Fiebig, Lena" sort="Fiebig, Lena" uniqKey="Fiebig L" first="Lena" last="Fiebig">Lena Fiebig</name><name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name><name sortKey="Soyka, Jana" sort="Soyka, Jana" uniqKey="Soyka J" first="Jana" last="Soyka">Jana Soyka</name><name sortKey="Von Kries, Rudiger" sort="Von Kries, Rudiger" uniqKey="Von Kries R" first="Rüdiger" last="Von Kries">Rüdiger Von Kries</name></noCountry><country name="Allemagne"><region name="Berlin"><name sortKey="Altmann, Mathias" sort="Altmann, Mathias" uniqKey="Altmann M" first="Mathias" last="Altmann">Mathias Altmann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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